Work Package 1

Literature investigation and country survey

Lead beneficiary:
University of Navarra, Pamplona, Spain

University of Navarra, Institute for Culture and Society logo


WP1 will contribute to the first objective of the research proposal: clarify the terminology, assessment, content and management of refractory suffering and the role of palliative sedation performing a literature investigation and a country survey.


Provided in the languages of the project team, each animated graphic in this section is a result of the research undertaken by the team of Work Package 1 and is intended for patients, carers and health professionals.

Select the language you would prefer to view the animated infographic then click or tap on each of the representative icons to view more information.

“Our group commissioned this infographic following our investigations into the current state of the art in the delivery of palliative sedation, including terminology used, through a comprehensive literature review and national surveys.”

Professor Carlos Centeno
University of Navarra


PDF IconDownload a copy of the full infographic in the relevant country language below:

Work Package 1 Team

“As the lead researcher for WP1, I will coordinate a team of researchers based in the University of Navarra, with the aim to clarify concept and terms and the assessment, and to explore the current practice and the role of palliative sedation in Europe.”

Carlos Centeno

Work Package 1 Lead

“I will be in charge of the systematic review on clinical studies on refractory symptoms and palliative sedation in palliative patients. We want to explore the published quality clinical evidence about palliative sedation and its effect on controlling symptoms that cannot be controlled with other treatment options to guide the best practice. “

Maria Arantzamendi


“I am going to review what has been written in previous scientific studies about Palliative Sedation and refractory symptoms. This review will collect data about different aspects of Palliative Sedation referring to the conceptual framework, clinical predictors, assessment procedures and treatment strategies. This information will give a theoretical framework where the study will be developed.”

Alazne Belar Beitia

PhD Student Researcher

“I will be mainly assisting in WP1, particularly responsible for Task 1.3: Online international survey for the collection of existing local guidelines for palliative sedation, regulations, equipment and to study the use and level of integration in health care practice in the participant countries.

Eduardo Garralda

Research Assistant

“Rocío will be conducting research in relation to Work Package 1, alongside colleagues at the University of Navarra.”

Rocío Rojí


Other Work Package Partners

We are grateful to the following project partners who worked with us in this work package:

Radboud University Medical Centre (WP2)
UZ Leuven (WP3)
University of Pecs (WP4)
University Hospital Bonn (WP6)
Lancaster University (WP7)
European Association for Palliative Care (WP8)
La Maddalena S.p.A. (MCC)

Current outcomes arising from WP1

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In addition to the creation of a multi-language infographic, the following publications have been published as a result of the research undertaken in this work package:

How to measure the effects and potential adverse events of palliative sedation? An integrative review
Belar A, Arantzamendi M, Payne S, Preston N, Rijpstra M, Hasselaar J, Radbruch L, Vanderelst M, Ling J, Centeno C. Palliative Medicine. 2020 Dec 14
Epub ahead of print. PMID: 33307989.
DOI: 10.1177/0269216320974264


Clinical Aspects of Palliative Sedation in Prospective Studies. A Systematic Review
Maria Arantzamendi, RN, PhD, Alazne Belar, RN, PhD, Sheila Payne, RN, PhD, Maaike Rijpstra, MSc, Nancy Preston, RN, PhD, Johan Menten, MD, PhD, Michael Van der Elst, MSc, Lukas Radbruch, MD, PhD, Jeroen Hasselaar, PhD and Carlos Centeno, MD, PhD Journal of pain and symptom management, 2020-09-19




Research in palliative care: who, how, and when? Core competencies framework
Carlos Centeno
Presented at the Romanian National Association of Palliative Care (ANIP) Conference, 22-23 October 2021
View PDF

Palliative Sedation – A European Perspective
Eduardo Garralda
Presented at the Romanian National Association of Palliative Care (ANIP) Conference, 22-23 October 2021
View PDF

Clinical aspects of Palliative sedation
María Arantzamendi
Presented at the first PalliativeSedation Webinar, 3rd June 2021
View PDF