The use of proportional palliative sedation for the relief of refractory symptoms: an international multi-centre study

An EU Horizon2020 Research Project

About the project

A €4 million project to investigate how best to help patients with distressing symptoms near the end of life will focus on the clinical, ethical, legal and moral aspects of providing sedation to dying patients across Europe.

“This research will focus on improved ways of assessing and managing refractory symptoms and the adequate use of palliative sedation, taking into account differences across Europe in both clinical and ethical aspects.”

Dr. Jeroen Hasselaar

Associate Professor Jeroen Hasselaar
Project Co-ordinator

Palliative sedation policy and practice across Europe: learning from the H2020 project

Palliative sedation policy and practice across Europe: learning from the H2020 project. The Palliative Sedation project aimed to investigate the best way to help patients with distressing symptoms near the end of life, focusing on clinical, ethical, legal and moral aspects. This webinar recording presents the main results of this 5-year study into palliative sedation, highlighting good practice in this area in different European countries. 

Consider joining of our free Massive, Open, Online Courses in 2024

Dying Well: The Role of Palliative Care and Sedation in End of Life Care.

A free, 3 week, online course, exploring how to help people experience better deaths.


Courses available:
20th May – 9th June 2024

Find out more

Consultation with a male doctor and patient

Watch our welcome trailer to the course.

An introduction to the project

Associate Professor Jeroen Hasselaar, the project co-ordinator, introduces the project and its aims.

Palliative Sedation eBook cover

The role of Palliative Sedation in palliative care

Released in September 2023, this free eBook covers the topic of palliative sedation and related subjects like definitions, ethics and practice in palliative sedation as well as the recently published EAPC framework on palliative sedation.

 View our dedicated page to read the eBook online

Our Goals:


To evidence and investigate the practice of proportional palliative sedation


To investigate the use of moral case deliberation for palliative sedation


To revise the 2009 EAPC recommended framework for palliative sedation


To increase public and professional understanding of palliative sedation

Palliative sedation at the end of life

An infographic created by the ATLANTES research team, University of Navarra, graphically demonstrating the terminologies and potential pathways incorporated into the current delivery of palliative sedation.


Behind the Scenes

An introduction to some of the research work being conducted within our Work Packages.

More details about the research being undertaken by each of the work packages can be found under the menu ‘Work Packages’.

Recent Activity

Project members held a one-day consortium meeting in the heart of Amsterdam on the 7th October 2022.

The meeting gave project members the opportunity to meet in person for the first time in years, presenting an excellent opportunity to reflect on the positive progress that each Work Package team has made. A consensus workshop was also made possible, along with a session where three consortium members were asked to present a challenging clinical case on palliative sedation.

photo of consortium members standing outside the meeting venue

‘Dying Well: The Role of Palliative Care and Sedation in End of Life Care" - new start date 20th May 2024.

Free access is for 3 weeks only, so register on or after the 19th of May.

Access the free link at the bottom of the webpage.

Palliative sedation is NOT assisted suicide - International Association for Hospice and Palliative Care Also information on joining our next MOOC 'Dying Well' @IOELC @EAPCvzw @LancsDHR @NancyPreston16

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Publications and other documents relating to the project can be found below.

Recent Publications

How to measure the effects and potential adverse events of palliative sedation? An integrative review
DOI: 10.1177/0269216320974264

Clinical Aspects of Palliative Sedation in Prospective Studies. A Systematic Review

Recent Presentations

The following presentations were given during a Palliative Sedation webinar, held on the 3rd June 2021.

Palliative sedation: Introduction

Clinical aspects of Palliative Sedation

Reflections on palliative sedation! Case presentations